The body naturally produces hyaluronic acid that adds volume and smoothness to skin. Perlane® is a hyaluronic acid gel that can be used to treat severe facial wrinkles, such as nasolabial folds (lines from the nose to the corners of the mouth), filling and smoothing the skin. Treatments typically last for about six months and can also be applied to the lips, cheeks, jowls, and other sagging facial skin.